abstract：:Chirality has become an increasingly important consideration in the development of psychoactive drugs because enantiomers often show major differences in their pharmacokinetic and pharmacologic properties. This review illustrates the implications of stereochemistry in clinical psychopharmacology using the antidepressa...

journal_title：CNS spectrums

authors： DeVane CL,Boulton DW

更新日期：2002-04-01 00:00:00

abstract：:We tested 28 individuals with schizophrenia (SZ) and 16 healthy individuals on a test of logical reasoning and "cognitive gating," defined as the ability to discriminate between relevant and irrelevant information in confirming or disconfirming a given belief. The Logical Reasoning and Cognitive Gating Task tests both...

journal_title：CNS spectrums

authors： Mujica-Parodi LR,Corcoran C,Greenberg T,Sackeim HA,Malaspina D

更新日期：2002-01-01 00:00:00

abstract：:The advent of the newer "atypical" antipsychotics has revolutionized pharmacologic treatment of schizophrenia (SZ) and other psychotic disorders. In contrast to the first-generation conventional neuroleptics, these second-generation antipsychotic agents possess a broader spectrum of efficacy and cause fewer motor side...

journal_title：CNS spectrums

authors： Tandon R,Jibson MD

更新日期：2001-12-01 00:00:00

abstract：:The medical records of 110 patients receiving conventional antipsychotics at two geographically distinct Veterans Administration hospitals (Syracuse, New York, and Omaha, Nebraska) were reviewed. The most common reasons for continuation of conventional antipsychotics were good response and patient or physician choice....

journal_title：CNS spectrums

authors： Masand PS,Arora M,Schwartz TL,Sharma A,Wang X,Bhatia S,Manjooran J,Hardoby W,Virk S,Kuhles DJ,Agharkar B,Gupta S

更新日期：2001-11-01 00:00:00

abstract：:This report describes the psychometric properties of the Self-Assessment of Resilience and Anxiety (SARA) scale within the context of a study of kava for generalized anxiety. This eight-item, patient-rated scale includes questions designed to measure calmness, mental clarity, confidence, physical well being, sociabili...

journal_title：CNS spectrums

authors： Barnett SD,Connor KM,Davidson JR

更新日期：2001-10-01 00:00:00

abstract：:Women with epilepsy are at risk for reproductive health dysfunction. Sex-steroid hormone abnormalities have been reported in women with epilepsy, but it has been difficult to determine whether these abnormalities are due to epilepsy-related hypothalamic-pituitary axis dysfunction, or to pharmacokinetic actions of anti...

journal_title：CNS spectrums

authors： Morrell MJ,Flynn KL,Seale CG,Done S,Paulson AJ,Flaster ER,Ferin M

更新日期：2001-09-01 00:00:00

abstract：:The latest and most generative biological theories of major depression center on two major hypotheses. The first focuses on the concept that hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis leads to many of the pathological changes in the brain that accompany major depression. The second posits that neur...

journal_title：CNS spectrums

authors： Perera T,Lisanby SH,Sackheim HA

更新日期：2001-07-01 00:00:00

abstract：:A subgroup of patients with childhood-onset obsessive-compulsive disorder (OCD) has been identified who share a common clinical course characterized by dramatic symptom exacerbations following Group A beta-hemolytic streptococcal (GABHS) infections. The term PANDAS has been applied to the subgroup, to indicate the pos...

journal_title：CNS spectrums

authors： Swedo SE,Garvey M,Snider L,Hamilton C,Leonard HL

更新日期：2001-05-01 00:00:00

abstract：:Kluver-Bucy syndrome (KBS) is a rare neuropsychiatric disorder that may be characterized by visual agnosia, placidity, altered sexual activity, hypermetamorphosis, and hyperorality. Patients with KBS present with a complex behavioral syndrome. KBS is usually associated with lesions of the amygdala or amygdaloid pathwa...

journal_title：CNS spectrums

authors： Carroll BT,Goforth HW,Raimonde LA

更新日期：2001-04-01 00:00:00

abstract：:Various aspects of personality or dispositional style predict risk for psychiatric disorders among adults. In particular, signs of neuroticism, emotional reactivity, or sensitivity to stress are strong predictors of later mood or anxiety disorders. The current report extends this literature to adolescents. An epidemio...

journal_title：CNS spectrums

authors： Pine DS,Cohen P,Brook JS

更新日期：2001-01-01 00:00:00

abstract：:Platelet dysfunction and thrombocytopenia rarely occur during clozapine therapy, but constitute an important source of morbidity and mortality if they are not detected and therapy is discontinued. The manufacturer recommends discontinuing clozapine when the platelet count falls below 100,000/muL and resuming therapy w...

journal_title：CNS spectrums

authors： Gonzales MF,Elmore J,Luebbert C

更新日期：2000-12-01 00:00:00

abstract：:This paper discusses the National Bioethics Advisory Commission's (NBAC's) report on research involving persons with mental disorders that may affect decisionmaking capacity. After placing the NBAC recommendations into their historic context, the authors propose a strategy to enroll decisionally incapacitated subjects...

journal_title：CNS spectrums

authors： Fins JJ,Miller FG

更新日期：2000-10-01 00:00:00

abstract：:Recent data suggest that the presence of psychotic symptoms in patients suffering from posttraumatic stress disorder (PTSD) may represent an underrecognized and unique subtype of PTSD. Among combat veterans with PTSD, 30% to 40% report auditory or visual hallucinations and/or delusions. The presence of psychotic sympt...

journal_title：CNS spectrums

authors： Lindley SE,Carlson E,Sheikh J

更新日期：2000-09-01 00:00:00

abstract：:The diagnosis of human immunodeficiency virus type 1 (HIV-1)-associated cognitive-motor disorder--either minor cognitive-motor disorder (MCMD) or HIV-1-associated dementia (HAD)--is fraught with potential pitfalls for the clinician. Before making such a diagnosis, clinicians should exclude other etiologies by using ne...

journal_title：CNS spectrums

authors： Goodkin K,Wilkie FL,Baldewicz TT,Concha M,Tyl MD,Lopiccolo CJ,Shapshak P

更新日期：2000-08-01 00:00:00

abstract：:The performance of nine adults with attention-deficit/hyperactivity disorder (ADHD) was compared with the performance of 23 normal controls on computerized measures of target orientation, sustained attention, encoding speed, and motor output/response organization to determine the nature of the neurocognitive deficits ...

journal_title：CNS spectrums

authors： Himelstein J,Halperin JM

更新日期：2000-06-01 00:00:00

abstract：:Psychopharmacology is rapidly becoming an adjuvant treatment to traditional rehabilitation strategies for patients with stroke or brain injury because it helps to facilitate recovery in a time-efficient manner. Norepinephrine, dopamine, acetylcholine, and serotonin appear to play important roles in recovery from strok...

journal_title：CNS spectrums

authors： Flanagan SR

更新日期：2000-03-01 00:00:00

abstract：:Combination pharmacotherapy has proven effective in a number of psychiatric disorders, including depression and schizophrenia. However, compared with other affective disorders, few studies have explored the use of combination therapy in alcoholism, and the majority have been limited to animal models. There is evidence...

journal_title：CNS spectrums

authors： Farren CK,Rezvani AH,Overstreet D,O'Malley S

更新日期：2000-02-01 00:00:00

abstract：:This article reviews the use of pharmacologic agents to treat nonparaphilic compulsive sexual behaviors (paraphilia-related disorders). Recent data suggest that serotonergic antidepressants, especially serotonin reuptake inhibitors (SRIs), may be effective in treating nonparaphilic sexual behaviors characterized by hy...

journal_title：CNS spectrums

authors： Kafka M

更新日期：2000-01-01 00:00:00

abstract：:This paper reviews the literature on gender differences in major depressive disorder (MDD) and bipolar disorder (BPD). Beginning in adolescence, women are at a higher risk than men of becoming depressed. Avenues of investigation that might ultimately help to explain this phenomenon include studies of gender difference...

journal_title：CNS spectrums

authors： Leibenluft E

更新日期：1999-10-01 00:00:00

abstract：:Although the incidence of cancer and cancer-related deaths has declined in recent years, undertreatment of cancer-related pain continues to be a significant problem. By thoroughly assessing chronic malignant pain (CMP) as it relates to cancer and achieving a more complete understanding of the CMP syndromes experienced...

journal_title：CNS spectrums

authors： Landolfi JC

更新日期：1999-09-01 00:00:00

abstract：:The use of different imaging modalities provides the clinician and researcher with different views of anatomy and physiology at unprecedented levels of detail. Multimodal imaging allows for noninvasive measurement of structure and function in humans during complex behavior, and thus provides information about the inne...

journal_title：CNS spectrums

authors： Salisbury DF,O'donnell BF,Nestor PG,Shenton ME,McCarley RW

更新日期：1999-01-01 00:00:00